Research

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Fluid Resuscitation in Tactical Combat Casualty Care; TCCC Guidelines Change 21-01
Deaton TG, Auten JD, Betzold R, Butler FK Jr, Byrne T, Cap AP, Donham B, DuBose JJ, Fisher AD, Hancock J, Jourdain V, Knight RM, Littlejohn LF, Martin MJ, Toland K, Drew B (2021)
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Balanced Resuscitation And Earlier Mortality End Points: Bayesian Post Hoc Analysis Of The PROPPR Trial
Lammers D, Rokayak O, Uhlich R, Sensing T, Baird E, Richman J, Holcomb JB, Jansen J. (2023)
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Earlier Time To Hemostasis Is Associated With Decreased Mortality And Rate Of Complications: Results From The Pragmatic Randomized Optimal Platelet And Plasma Ratio (PROPPR) Trial
Chang R, Kerby JD, Kalkwarf KJ, Van Belle G, Fox EE, Cotton BA, Cohen MJ, Schreiber MA, Brasel K, Bulger EM, Inaba K, Rizoli S, Podbielski JM, Wade CE, Holcomb JB; PROPPR Study Group. (2019)
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Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis Of The PAMPer Cluster Randomized Clinical Trial
Gruen, D. S., Guyette, F. X., Brown, J. B., Okonkwo, D. 0., Puccio, A. M., Campwala, I. K., Tessmer, M. T., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Neal, M. D., Zuckerbraun, B. S., Yazer, M. H., Billiar, T. R., & Sperry, J. L. (2020)
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Bleeding to death In A Big City: An Analysis Of All Trauma Deaths From Hemorrhage In A Metropolitan Area During 1 Year
Kalkwarf KJ, Drake SA, Yang Y, Thetford C, Myers L, Brock M, Wolf DA, Persse D, Wade CE, Holcomb JB. (2020).
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Access To Immediately Available Balanced Blood Products In A Rural State’s Trauma System
Smedley WA, Mabry CD, Collins T, Tabor J, Bowman S, Porter A, Young S, Klutts G, Deloach J, Bhavaraju A, Maxson T, Robertson RD, Holcomb JB, Kalkwarf KJ. (2023).
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Quantifying The Benefit Of Whole Blood On Mortality In Trauma Patients Requiring Emergent Laparotomy
Lammers D, Betzold R, McClellan J, Eckert M, Bingham J, Hu P, Hurst S, Baird E, Hashmi Z, Kerby J, Jansen JO, Holcomb JB. (2024).
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Removing The Barriers To Prehospital Blood: A Roadmap To Success
Schaefer RM, Bank EA, Krohmer JR, Haskell A, Taylor AL, Jenkins DH, Holcomb JB. (2024).
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Finding The Bleeding Edge: 24-Hour Mortality By Unit Of Blood Product Transfused In Combat Casualties From 2002-2020
Gurney JM, Staudt AM, Holcomb JB, Martin M, Spinella P, Corley JB, Rohrer AJ, Trevino JD, Del Junco DJ, Cap A, Schreiber M. (2023)
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Making Blood Immediately Available In Emergencies
Holcomb JB, Butler FK, Schreiber MA, Taylor AL, Riggs LE, Krohmer JR, Dorlac WC, Jenkins DH, Cox DB, Beckett AN, O'Connor KC, Gurney JM. (2024)
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A Review Of Attitudes To Urgent RhD-Positive Transfusions In Female Patients And The Risk For Hemolytic Disease Of The Fetus And Newborn.
Yazer MH, Spinella PC, Holcomb JB, Horvath S, Sherwood MR, Emery SP, Leonard JC, Leeper CM (2024)
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The Females Have Spoken. A Patient-Centered National Survey On The Administration Of Emergent Transfusions With The Potential For Future Fetal Harm
Uhlich, R., Hu, P., Yazer, M., Jansen, J. O., Patrician, P., Marques, M. B., Reynolds, L., Fifolt, M., Stephens, S. W., Gelbard, R. B., Kerby, J., & Holcomb, J. B. (2023).
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Pre-Hospital Transfusion Of Red Blood Cells. Part 1: A Scoping Review Of Current Practice And Transfusion Triggers
Turenhout, E. C., Bossers, S. M., Loer, S. A., Giannakopoulos, G. F., Schwarte, L. A., & Schober, P. (2020).
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Association Of Red Blood Cells And Plasma Transfusion Versus Red Blood Cell Transfusion Only With Survival For Treatment of Major Traumatic Hemorrhage In Prehospital Setting In England: A Multicenter Study
Tucker, H., Brohi, K., Tan, J., Aylwin, C., Bloomer, R., Cardigan, R., Davenport, R., Davies, E. D., Godfrey, P., Hawes, R., Lyon, R., McCullagh, J., Stanworth, S., Thompson, J., Uprichard, J., Walsh, S., Weaver, A., & Green, L. (2023).
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The U.S. Armed Services Blood Program Support To U.S. Central Command 2014-2021: Transformation Of Combat Trauma Resuscitation Through Blood Product Innovation And Expansion of Blood Availability Far Forward
Taylor, A. L., Corley, J. B., Cap, A. P., Swingholm, M. T., Nance, E. T., Gonzales, R., Gurney, J. M., Shackelford, S., Hebert, J. C., Hughes, J. D., Royster, K., Hestilow, G. A., Cordrick, C. L., Hoiles, J., Whitlock, K., Whitacre, R., & Pederson, B. (2022).
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Fresh Whole Blood Transfusions In Coalition Military, Foreign National, And Enemy Combatant Patients During Operation Iraqi Freedom at a U.S. Combat Support Hospital
Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Repine, T., Beekley, A. C., Sebesta, J., Jenkins, D., Aza row, K., Holcomb, J. B., Chiles, J., Blackbourne, L., Nichols, D., Greco, J., Clagett, C., & Thibault, G. (2008).
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Warm Fresh Whole Blood is Independently Associated With Improved Survival For Patients With Combat-Related Traumatic Injuries
Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Beekley, A. C., & Holcomb, J. B. (2009)
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Prehospital Plasma During Air Medical Transport In Trauma Patients At Risk For Hemorrhagic Shock
Sperry, J. L., Guyette, F. X., Brown, J. B., Yazer, M. H., Triulzi, D. J., Early-Young, B. J., Adams, P. W., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Witham, W. R., Putnam, A. T., Duane, T. M., Alarcon, L. H., Callaway, C. W., Zuckerbraun, B. S., Neal, M. D., ... Zenati, M. S. (2018).
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Joint Trauma System, Defense Committee On Trauma, and Armed Services Blood Program Consensus Statement On Whole Blood
Shackelford, S. A., Gurney, J. M., Taylor, A. L., Keenan, S., Corley, J. B., Cunningham, C. W., Drew, B. G., Jensen, S. D., Kotwal, R. S., Montgomery, H. R., Nance, E. T., Remley, M. A., & Cap, A. P. (2021).
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Association of Prehospital Blood Product Transfusion During Medical Evacuation of Combat Casualties in Afghanistan With Acute And 30-day Survival
Shackelford, S. A., Del Junco, D. J., Powell-Dunford, N., Mazuchowski, E. L., Howard, J. T., Kotwal, R. S., Gurney, J., Butler, F. K., Gross, K., & Stockinger, Z. T. (2017).
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Risk Factors For The Development of Acute Respiratory Distress Syndrome Following Hemorrhage
Robinson, B. R. H., Cohen, M. J., Holcomb, J. B., Pritts, T. A., Gomaa, D., Fox, E. E., Branson, R. D., Callcut, R. A., Cotton, B. A., Schreiber, M. A., Brasel, K. J., Pittet, J. F., Inaba, K., Kerby, J. D., Scalea, T. M., Wade, C. E., & Bulger, E. M. (2018)
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Association of Prehospital Plasma Transfusion with Survival in Trauma Patients with Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials
Pusateri, A. E., Moore, E. E., Moore, H. B., Le, T. D., Guyette, F. X., Chapman, M. P., Sauaia, A., Ghasabyan, A., Chandler, J., McVaney, K., Brown, J. B., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Witham, W. R., Putnam, A. T., & Sperry, J. L. (2020).
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Practice Guidelines For Perioperative Blood transfusion and adjuvant therapies: An Updated Report By The American Society of Anesthesiologists Task Force On Perioperative Blood Transfusion And Adjuvant Therapies
Nuttall, G. A., Brost, B. C., Connis, R. T., Gessner, J. S., Harrison, C. R., Miller, R. D., Nickinovich, D. G., Nussmeier, N. A., Rosenberg, A. D., & Spence, R. (2006).
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Every Minute Counts: Time To delivery Of Initial Massive Transfusion Cooler And Its Impact On Mortality
Meyer, D. E., Vincent, L. E., Fox, E. E., O'Keeffe, T., Inaba, K., Bulger, E., Holcomb, J. B., & Cotton, B. A. (2017).
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United States Army Rangers in Somalia: An Analysis of Combat Casualties on an Urban Battlefield
Mabry, R. L., Holcomb, J. B., Baker, A. M., Cloonan, C. C., Uhorchak, J. M., Perkins, D. E., Canfield, A. J., & Hagmann, J. H. (2000).
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Evaluating The Cost-Effectiveness Of Prehospital Plasma Transfusion in Unstable Trauma Patients: A Secondary Analysis of the PAMPer Trial
Hrebinko, K. A., Sperry, J. L., Guyette, F. X., Brown, J. B., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Neal, M. D., Zuckerbraun, B. S., Yazer, M. H., & Nicholson, K. J. (2021).
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Transfusion Of Plasma, Platelets, And Red Blood Cells In A 1:1:1 vs A 1:1:2 Ratio And Mortality In Patients With Severe Trauma: The PROPPR Randomized Clinical Trial
Holcomb, J. B., Tilley, B.C., Baraniuk, S., Fox, E. E., Wade, C. E., Podbielski, J. M., Del Junco, D. J., Brasel, K. J., Bulger, E. M., Callcut, R. A., Cohen, M. J., Cotton, B. A., Fabian, T. C., Inaba, K., Kerby, J. D., Muskat, P., O'Keeffe, T., Rizoli, S., Robinson, B. R. H., ... Van Belle, G. (2015).
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Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma
Holcomb, J. B., Jenkins, D., Rhee, P., Johannigman, J., Mahoney, P., Mehta, S., Cox, E. D., Gehrke, M. J., Beilman, G. J., Schreiber, M., Flaherty, S. F., Grathwohl, K. W., Spinella, P. C., Perkins, J. G., Beekley, A. C., McMullin, N. R., Park, M. S., Gonzalez, E. A., Wade, C. E., ... Hess, J. R. (2007)
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Nationwide Estimates Of The Need For Prehospital Blood Products After Injury
Hashmi, Z. G., Jansen, J. 0., Kerby, J. D., & Holcomb, J. B. (2022).
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Prehospital Low Titer Group 0 Whole Blood Is Feasible And Safe: Results Of A Prospective Randomized Pilot Trial
Guyette, F. X., Zenati, M., Triulzi, D. J., Yazer, M. H., Skroczky, H., Early, B. J., Adams, P. W., Brown, J. B., Alarcon, L., Neal, M. D., Forsythe, R. M., Zuckerbraun, B. S., Peitzman, A. B., Billiar, T. R., & Sperry, J. L. (2022).
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Clinical Review: Canadian National Advisory Committee On Blood And Blood Products – Massive Transfusion Consensus Conference 2011: Report Of The Panel
Dzik, W. H., Blajchman, M. A., Fergusson, D., Hameed, M., Henry, B., Kirkpatrick, A. W., Korogyi, T., Logsetty, S., Skeate, R. C., Stanworth, S., MacAdams, C., & Muirhead, B. (2011).
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Resuscitate Early With Plasma And Platelets Or Balance Blood Products Gradually: Findings From The PROMMTT Study
Del Junco, D. J., Holcomb, J. B., Fox, E. E., Brasel, K. J., Phelan, H. A., Bulger, E. M., Schreiber, M. A., Muskat, P., Alarcon, L. H., Cohen, M. J., Cotton, B. A., Wade, C. E., Myers, J. G., & Rah ba r, M. H. (2013).
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Time To Early Resuscitative Intervention Association With Mortality In Trauma Patients At Risk For Hemorrhage
Deeb, A.-P., Guyette, F. X., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Eastridge, B. J., Joseph, B., Nirula, R., Vercruysse, G. A., Sperry, J. L., & Brown, J. B. (2023).
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An Analysis Of Prehospital Deaths: Who Can We Save?
Davis, J. S., Satahoo, S. S., Butler, F. K., Dermer, H., Naranjo, D., Julien, K., Van Haren, R. M., Namias, N., Blackbourne, L. H., & Schulman, C. I. (2014).
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A Randomized Controlled Pilot Trial Of Modified Whole Blood Versus Component Therapy In Severely Injured Patients Requiring Large Volume Transfusions
Cotton, B. A., Podbielski, J., Camp, E., Welch, T., Del Junco, D., Bai, Y., Hobbs, R., Scroggins, J., Hartwell, B., Kozar, R. A., Wade, C. E., & Holcomb, J. B. (2013).
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Prehospital Hemorrhage Control and Treatment by Clinicians: A Joint Position Statement. Prehospital Emergency Care
Berry, C., Gallagher, J. M., Goodloe, J. M., Dorlac, W. C., Dodd, J., & Fischer, P. E. (2023).
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The Ratio of Blood Products Transfused Affects Mortality In Patients Receiving Massive Transfusions At A Combat Support Hospital
Borgman, M. A., Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Repine, T., Beekley, A. C., Sebesta, J., Jenkins, D., Wade, C. E., & Holcomb, J. B. (2007).
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Fluid Resuscitation for Hemorrhagic Shock In Tactical Combat Casualty Care: TCCC Guidelines Change 14-01–2 June 2014
Butler FK Jr, Holcomb JB, Schreiber MA, Kotwal RS, Jenkins DA, Champion HR, Bowling F, Cap AP, DuBose JJ, Dorlac WC, Dorlac GR, McSwain NE, Timby JW, Blackbourne LH, Stockinger Z, Strandenes G, Weiskopf RB, Gross K, Bailey JA. (2024).
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Cost-Effectiveness Evaluation Of The PROPPR Trial Transfusion Protocols
Callcut, R. A., Simpson, K. N., Baraniuk, S., Fox, E. E., Tilley, B. C., & Holcomb, J. B. (2020).
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Hemorrhagic Shock
Cannon, J. W. (2018).
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Damage Control Resuscitation in Patients With Severe Traumatic Hemorrhage: A Practice Management Guideline From The Eastern Association For The Surgery of Trauma
Cannon, J. W., Khan, M. A., Raja, A. S., Cohen, M. J., Como, J. J., Cotton, B. A., Dubose, J. J., Fox, E. E., Inaba, K., Rodriguez, C. J., Holcomb, J. B., & Duchesne, J. C. (2017).
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Platelet Transfusions Improve Hemostasis and Survival In A Substudy Of The Prospective, Randomized PROPPR Trial
Jessica C. Cardenas, Xu Zhang, Erin E. Fox, Bryan A. Cotton, John R. Hess, Martin A. Schreiber, Charles E. Wade, John B. Holcomb on behalf of the PROPPR Study Group.
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The Story of Blood For Shock Resuscitation: How The Pendulum Swings
Carmichael, S. P., Lin, N., Evangelista, M. E., & Holcomb, J. B. (2021).
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