Research

Prehospital References
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Black, J. A., Pierce, V. S., Juneja, K., & Holcomb, J. B. (2021). Complications of Hemorrhagic Shock and Massive Transfusion-a Comparison Before and After the Damage Control Resuscitation Era. Shock (Augusta, Ga.), 56(1), 42-51. https://doi.org/10.1097/SHK.0000000000001676
Borgman, M. A., Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Repine, T., Beekley, A. C., Sebesta, J., Jenkins, D., Wade, C. E., & Holcomb, J. B. (2007). The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. Journal of Trauma - Injury, Infection and Critical Care, 63(4), 805-813. https://doi.org/10.1097/TA.0b013e3181271ba3
Butler, F. K., Holcomb, J. B., Schreiber, M. A., Kotwal, R. S., Jenkins, D. A., Champion, H. R., Bowling, F., Cap, A. P., DuBose, J. J., Dorlac, W. C., Dorlac, G. R., McSwain, N. E., Timby, J. W., Blackbourne, L. H., Stockinger, Z., Strandenes, G., Weiskopf, R. B., Gross, K., & Bailey, J. A. (2014). Fluid Resuscitation for Hemorrhagic Shock in Tactical Combat Casualty Care: TCCC Guidelines Change 14-01- 2 June 2014. Journal of Special Operations Medicine, 14(3), 13. https://dolorg/10.55460/DPOC-JWIY
Callcut, R. A., Simpson, K. N., Baraniuk, S., Fox, E. E., Tilley, B. C., & Holcomb, J. B. (2020). Cost-effectiveness evaluation of the PROPPR trial transfusion protocols. Transfusion, 60(5), 922-931. https://doi.org/10.1111/trf.15784
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Cardenas, J. C., Zhang, X., Fox, E. E., Cotton, B. A., Hess, J. R., Schreiber, M. A., Wade, C. E., Holcomb, J. B., Holco, J. B., Del Junco, D. J., Matijevic, N., Podbielski, J., Beeler, A. M., Tilley, B. C., Baraniuk, S., Zhu, H., Nixon, J., Seay, R., Appana, S. N., ... Colavecchia, C. (2018). Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial. Blood Advances, 2(14), 1696-1704. https://doi.org/10.1182/bloodadvances.2018017699
Carmichael, S. P., Lin, N., Evangelista, M. E., & Holcomb, J. B. (2021). The Story of Blood for Shock Resuscitation: How the Pendulum Swings. Journal of the American College of Surgeons, 233(5), 644-653. https://doi.org/10.1016/j.jamcollsurg.2021.08.001 CMS, CM, PCG, & Dpipd. (2018). AMBULANCE FEE SCHEDULE AND MEDICARE TRANSPORTS PRINT-FRIENDLY VERSION CPT Disclaimer-American Medical Association (AMA) Notice CPT codes.
Cotton, B. A., Podbielski, J., Camp, E., Welch, T., Del Junco, D., Bai, Y., Hobbs, R., Scroggins, J., Hartwell, B., Kozar, R. A., Wade, C. E., & Holcomb, J. B. (2013). A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Annals of Surgery, 258(4), 527-532. https://doi.org/10.1097/SLA.0b013e3182a4ffa0
Davis, J. S., Satahoo, S. S., Butler, F. K., Dermer, H., Naranjo, D., Julien, K., Van Haren, R. M., Namias, N., Blackbourne, L. H., & Schulman, C. I. (2014). An analysis of prehospital deaths: Who can we save? Journal of Trauma and Acute Care Surgery, 77(2), 213-218. https://doi.org/10.1097/TA.0000000000000292
Deeb, A.-P., Guyette, F. X., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Eastridge, B. J., Joseph, B., Nirula, R., Vercruysse, G. A., Sperry, J. L., & Brown, J. B. (2023). Time to early resuscitative intervention association with mortality in trauma patients at risk for hemorrhage. Journal of Trauma and Acute Care Surgery, 94(4), 504-512. https://doi.org/10.1097/TA.0000000000003820
Del Junco, D. J., Holcomb, J. B., Fox, E. E., Brasel, K. J., Phelan, H. A., Bulger, E. M., Schreiber, M. A., Muskat, P., Alarcon, L. H., Cohen, M. J., Cotton, B. A., Wade, C. E., Myers, J. G., & Rah ba r, M. H. (2013). Resuscitate early with plasma and platelets or balance blood products gradually: Findings from the PROMMTT study. Journal of Trauma and Acute Care Surgery, 75(1 SUPPL1). https://doi.org/10.1097/TA.0b013e31828fa3b9
Dzik, W. H., Blajchman, M. A., Fergusson, D., Hameed, M., Henry, B., Kirkpatrick, A. W., Korogyi, T., Logsetty, S., Skeate, R. C., Stanworth, S., MacAdams, C., & Muirhead, B. (2011). Clinical review: Canadian National Advisory Committee on Blood and Blood Products - Massive Transfusion Consensus Conference 2011: Report of the panel. In Critical Care (Vol. 15, Issue 6). https://doi.org/10.1186/cc10498
Gruen, D. S., Guyette, F. X., Brown, J. B., Okonkwo, D. 0., Puccio, A. M., Campwala, I. K., Tessmer, M. T., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Neal, M. D., Zuckerbraun, B. S., Yazer, M. H., Billiar, T. R., & Sperry, J. L. (2020b). Association of Prehospital Plasma with Survival in Patients with Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial. JAMA Network Open, 3(10). https://doi.org/10.1001/jamanetworkopen.2020.16869
Guyette, F. X., Zenati, M., Triulzi, D. J., Yazer, M. H., Skroczky, H., Early, B. J., Adams, P. W., Brown, J. B., Alarcon, L., Neal, M. D., Forsythe, R. M., Zuckerbraun, B. S., Peitzman, A. B., Billiar, T. R., & Sperry, J. L. (2022). Prehospital low titer group 0 whole blood is feasible and safe: Results of a prospective randomized pilot trial. Journal of Trauma and Acute Care Surgery, 92(5), 839-847. https://doi.org/10.1097/TA.0000000000003551
Hashmi, Z. G., Chehab, M., Nathens, A. B., Joseph, B., Bank, E. A., Jansen, J. 0., & Holcomb, J. B. (2021). Whole truths but half the blood: Addressing the gap between the evidence and practice of pre-hospital and in-hospital blood product use for trauma resuscitation. Transfusion, 61(S1), S348-S353. https://doi.org/10.1111/trf.16515
Hashmi, Z. G., Jansen, J. 0., Kerby, J. D., & Holcomb, J. B. (2022). Nationwide estimates of the need for prehospital blood products after injury. Transfusion, 62(S1), S203-S210. https://doi.org/10.1111/trf.16991 > Holcomb, C. J. B. (2003). Fluid Resuscitation in Modern Combat Casualty Care: Lessons Learned from Somalia. Journal of Trauma: Injury, Infection & Critical Care, 54(5), S46-S51. https://doi.org/10.1097/01.TA.0000051936.91915.A2
Holcomb, J. B. (2011). Reconstitution: Reverse Engineering. Journal of Trauma: Injury, Infection & Critical Care, 70(5), S65-S67. https://doi.org/10.1097/TA.0b013e31821a609c
Holcomb, J. B., Jenkins, D., Rhee, P., Johannigman, J., Mahoney, P., Mehta, S., Cox, E. D., Gehrke, M. J., Beilman, G. J., Schreiber, M., Flaherty, S. F., Grathwohl, K. W., Spinella, P. C., Perkins, J. G., Beekley, A. C., McMullin, N. R., Park, M. S., Gonzalez, E. A., Wade, C. E., ... Hess, J. R. (2007). Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma. Journal of Trauma: Injury, Infection & Critical Care, 62(2), 307-310. https://doi.org/10.1097/TA.0b013e3180324124
Holcomb, J. B., & Pati, S. (2013). Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon's perspective. In Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program (Vol. 2013, pp. 656-659). https://doi.org/10.1182/asheducation-2013.1.656
Holcomb, J. B., Tilley, B.C., Baraniuk, S., Fox, E. E., Wade, C. E., Podbielski, J. M., Del Junco, D. J., Brasel, K. J., Bulger, E. M., Callcut, R. A., Cohen, M. J., Cotton, B. A., Fabian, T. C., Inaba, K., Kerby, J. D., Muskat, P., O'Keeffe, T., Rizoli, S., Robinson, B. R. H., ... Van Belle, G. (2015). Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial. JAMA - Journal of the American Medical Association, 313(5), 471-482. https://doi.org/10.1001/ jama.2015.12
Hrebinko, K. A., Sperry, J. L., Guyette, F. X., Brown, J. B., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Neal, M. D., Zuckerbraun, B. S., Yazer, M. H., & Nicholson, K. J. (2021). Evaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients: A Secondary Analysis of the PAMPer Trial. JAMA Surgery, 156(12), 1131-1139. https://doi.org/10.1001/jamasurg.2021.4529
Mabry, R. L., Holcomb, J. B., Baker, A. M., Cloonan, C. C., Uhorchak, J. M., Perkins, D. E., Canfield, A. J., & Hagmann, J. H. (2000). United States Army Rangers in Somalia: An Analysis of Combat Casualties on an Urban Battlefield. In J Trauma (Vol. 49).
Meyer, D. E., Vincent, L. E., Fox, E. E., O'Keeffe, T., Inaba, K., Bulger, E., Holcomb, J. B., & Cotton, B. A. (2017). Every minute counts: Time to delivery of initial massive transfusion cooler and its impact on mortality. Journal of Trauma and Acute Care Surgery, 83(1),19-24. https://doi.org/10.1097/TA.0000000000001531
Munjal, K. G., Margolis, G. S., & Kellermann, A. L. (2019). Realignment of EMS Reimbursement Policy: New Hope for Patient-Centered Out-of-Hospital Care. In JAMA - Journal of the American Medical Association (Vol. 322, Issue 4, pp. 303-304). American Medical Association. https://doi.org/10.1001/jama.2019.7488
Nuttall, G. A., Brost, B. C., Connis, R. T., Gessner, J. S., Harrison, C. R., Miller, R. D., Nickinovich, D. G., Nussmeier, N. A., Rosenberg, A. D., & Spence, R. (2006). Practice guidelines for perioperative blood transfusion and adjuvant therapies: An updated report by the American Society of Anesthesiologists Task Force on perioperative blood transfusion and adjuvant therapies. In Anesthesiology (Vol.105, Issue 1, pp.198-208). https://doi.org/10.1097/00000542-200607000-00030
Pusateri, A. E., Moore, E. E., Moore, H. B., Le, T. D., Guyette, F. X., Chapman, M. P., Sauaia, A., Ghasabyan, A., Chandler, J., McVaney, K., Brown, J. B., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Witham, W. R., Putnam, A. T., & Sperry, J. L. (2020). Association of Prehospital Plasma Transfusion with Survival in Trauma Patients with Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials. JAMA Surgery, 155(2). https:// doi.org/10.1001/jamasurg.2019.5085
Robinson, B. R. H., Cohen, M. J., Holcomb, J. B., Pritts, T. A., Gomaa, D., Fox, E. E., Branson, R. D., Callcut, R. A., Cotton, B. A., Schreiber, M. A., Brasel, K. J., Pittet, J. F., Inaba, K., Kerby, J. D., Scalea, T. M., Wade, C. E., & Bulger, E. M. (2018). Risk factors for the development of acute respiratory distress syndrome following hemorrhage. Shock, 50(3), 258-264. https://doi.org/10.1097/SHK.0000000000001073
Shackelford, S. A., Del Junco, D. J., Powell-Dunford, N., Mazuchowski, E. L., Howard, J. T., Kotwal, R. S., Gurney, J., Butler, F. K., Gross, K., & Stockinger, Z. T. (2017). Association of prehospital blood product transfusion during medical evacuation of combat casualties in Afghanistan with acute and 30-day survival. JAMA - Journal of the American Medical Association, 318(16),1581-1591. https://doi.org/10.1001/jama.2017.15097
Shackelford, S. A., Gurney, J. M., Taylor, A. L., Keenan, S., Corley, J. B., Cunningham, C. W., Drew, B. G., Jensen, S. D., Kotwal, R. S., Montgomery, H. R., Nance, E. T., Remley, M. A., & Cap, A. P. (2021). Joint Trauma System, Defense Committee on Trauma, and Armed Services Blood Program consensus statement on whole blood. Transfusion, 61(S1), S333-S335. https://doi.org/10.1111/trf.16454
Sperry, J. L., Guyette, F. X., Brown, J. B., Yazer, M. H., Triulzi, D. J., Early-Young, B. J., Adams, P. W., Daley, B. J., Miller, R. S., Harbrecht, B. G., Claridge, J. A., Phelan, H. A., Witham, W. R., Putnam, A. T., Duane, T. M., Alarcon, L. H., Callaway, C. W., Zuckerbraun, B. S., Neal, M. D., ... Zenati, M. S. (2018). Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock. New England Journal of Medicine, 379(4), 315-326. https://doi.org/10.1056/nejmoa1802345
Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Beekley, A. C., & Holcomb, J. B. (2009). Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. Journal of Trauma - Injury, Infection and Critical Care, 66(SUPPL. 4). https://doi.org/10.1097/TA.0b013e31819d85fb
Spinella, P. C., Perkins, J. G., Grathwohl, K. W., Repine, T., Beekley, A. C., Sebesta, J., Jenkins, D., Aza row, K., Holcomb, J. B., Chiles, J., Blackbourne, L., Nichols, D., Greco, J., Clagett, C., & Thibault, G. (2008). Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during operation Iraqi freedom at a U.S. combat support hospital. World Journal of Surgery, 32(1), 2-6. https://doi.org/10.1007/s00268-007-9201-5
Taylor, A. L., Corley, J. B., Cap, A. P., Swingholm, M. T., Nance, E. T., Gonzales, R., Gurney, J. M., Shackelford, S., Hebert, J. C., Hughes, J. D., Royster, K., Hestilow, G. A., Cordrick, C. L., Hoiles, J., Whitlock, K., Whitacre, R., & Pederson, B. (2022). The U.S. Armed Services Blood Program support to U.S. Central Command 2014-2021: Transformation of combat trauma resuscitation through blood product innovation and expansion of blood availability far forward. Transfusion, 62(S1), 167-S176. https://doi.org/10.1111/trf.16951
Tompeck AJ, et al. A comprehensive review of topical hemostatic agents: The good, the bad, and the novel. Journal of Trauma and Acute Care Surgery 88(1):p el-e21, January 2020.
Tucker, H., Brohi, K., Tan, J., Aylwin, C., Bloomer, R., Cardigan, R., Davenport, R., Davies, E. D., Godfrey, P., Hawes, R., Lyon, R., McCullagh, J., Stanworth, S., Thompson, J., Uprichard, J., Walsh, S., Weaver, A., & Green, L. (2023). Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study. Critical Care, 27(1). https://doi.org/10.1186/s13054-022-04279-4
Turenhout, E. C., Bossers, S. M., Loer, S. A., Giannakopoulos, G. F., Schwarte, L. A., & Schober, P. (2020). Pre-hospital transfusion of red blood cells. Part 1: A scoping review of current practice and transfusion triggers. Transfusion Medicine, 30(2), 86-105. https://doi.org/10.1111/tme.12667
Uhlich, R., Hu, P., Yazer, M., Jansen, J. O., Patrician, P., Marques, M. B., Reynolds, L., Fifolt, M., Stephens, S. W., Gelbard, R. B., Kerby, J., & Holcomb, J. B. (2023). The females have spoken. A patient-centered national survey on the administration of emergent transfusions with the potential for future fetal harm. Journal of Trauma and Acute Care Surgery. https://doi.org/10.1097/TA.0000000000003914
Yazer, M. H., Triulzi, D. J., Sperry, J. L., & Seheult, J. N. (2021). Rate of RhD-alloimmunization after the transfusion of multiple RhD-positive primary red blood cell-containing products. Transfusion, 61(S1), S150-S158. https://doi.org/10.1111/trf.16495
Research Reference